Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 2nd Annual Congress on Diabetes and its Complications Hong Kong.

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Scientific Program Day 1

Day :

  • Prevention of Diabetes | Diabetes: Types & Pathophysiology | Diabetic Nephropathy| Glaucoma | Diabetes & Cancer | Probiotics and Antimicrobial Proteins | Probiotics in Diabetes | Functional Foods
Location: Ball Room 3

Session Introduction

Katarzyna W Jasinska

Jagiellonian University Medical College, Poland

Title: Probiotics as functional food in neurocognitive disorder
Speaker
Biography:

Katarzyna W Jasinska is a Junior Researcher from Faculty of Medicine, Jagiellonian University Medical College in Cracow, Poland. She is an author of several published papers and numerous congress presentations. Her main research interests are probiotics and bariatric.

Abstract:

Introduction & Aim: Probiotics are living micro-organisms which may confer a health benefit on the host, allowing consider them as functional food. Numerous evidences suggest that probiotics have advantageous impact on diseases such as constipation, several types of diarrhea, irritable bowel syndrome, melioration of lactose intolerance, inhibition of Helicobacter pylori and reduction in serum cholesterol level. However, current evidence on the effect of probiotics on neurocognitive functions is limited. This systematic review aims to assess the efficacy of probiotics in dementia.

Methods: This is a systematic review conducted following Cochrane Handbook for Systematic Reviews of Interventions. Protocol of the study has been registered in PROSPERO at CRD42019123490. We have searched four electronic databases, three clinical trial registers and carried out a hand searching to find relevant studies. All titles and abstracts of studies were reviewed independently by two reviewers and eligible full texts were assessed similarly. To assess risk of bias in included studies we use Cochrane Risk of Bias Tool for RCTs.

Results: Searching identified 3088 records (3071 from databases and 17 additional from clinical trials registers). After removing duplicates, we screened 2548 references. We included 12 papers into full texts screening, 7 of them was included into qualitative synthesis. Main interventions used were Lactobacilli and Bifidobacteria. Predominantly evaluated dementia was related to Alzheimer’s disease and predementia state was related to minimal hepatic encephalopathy. All of the included studies have shown improvement in cognitive function in predementia, nevertheless results for severe dementia seems to be uncertain. One of the papers presents increase in quality of life after probiotic administration.

Conclusion: This review suggests the potential advantages of using probiotics in neurocognitive disorder. However, this field seems to be unexplored and more high quality RCTs is needed.

Laksmi Hartajanie

Diponegoro University, Indonesia

Title: Fermented bitter melon juice as complimentary promising agent for diabetes type 2 treatment
Speaker
Biography:

Laksmi Hartajanie has completed her PhD from Diponegoro University, Faculty of Medicine. She is a Senior Lecturer of Soegijapranata Catholic University, Faculty of Food Technology.

Abstract:

Momordica charantia (Bitter melon) contains substance with antidiabetic properties such as charantin that has anti-oxidative properties. Oxidative stress plays a major role in the pathogenesis and progression of metabolic syndrome such as diabetes. In the present study, a total of 30 male Sprague-Dawley rats were used. Diabetes type-2 was induced by a single dose (60 mg/kg) of Streptozotocin (STZ), intravenous injection. Following three days of STZ induction, the animals were randomly divided into five groups (n=6); diabetic group treated with Acarbose 40 mg/100 g feed (DM-Ac), diabetic group treated with MC (DM-MC), diabetic group treated with Probiotic 1 MC (DM-PMC1), diabetic group treated with probiotic 2 MC (DM-PMC2) and diabetic untreated group (DM-Ctrl). Oral administration of the MC fruit extract (10 ml/kg body weight) was continued for 28 days. All groups treated with MC (non-fermented and fermented) showed a significant decreased (P<0.05) in fasting blood glucose and post prandial blood glucose compared to the DM-Ctrl group. SOD level was significantly increased in MC groups. These results suggest that fermented bitter melon juice is a promising complimentary agent for diabetes type-2 treatment.

Dede Mahdiyah

Diponegoro University, Indonesia

Title: Antibiotics properties of peat lands bacteria
Speaker
Biography:

Dede Mahdiyah is a PhD candidate from Diponegoro University, Indonesia. She is currently working as a Lecturer and as Head of Research and Community Services of Sari Mulia University, Banjarmasin, South of Kalimantan.

Abstract:

The widespread use of antibiotics to treat infectious diseases causes a global increase of resistant bacteria, whereas a discovery of new antibiotics was very rare due to high expenses. Peat land has an extreme and unique environment therefore an adapted bacterial flora may has special metabolic properties which contain has antimicrobial like substances. The purpose of this study was to identify the characteristics of antibiotic like substances produced by peat soil bacteria. The TSA media incubate at 30oC for two days was used to isolate the bacteria. The isolated colonies were identified and followed by Gram staining and catalase test. Antimicrobial activity test towards Salmonella Typhi was done using diffusion wells method, incubate at 37oC for 24 hours and chloramphenicol disk was used as control. Molecular weight was determined by SDS PAGE electrophoresis. The characteristics of bacteria were Gram negative cocci, positive catalase with molecular weight of 43 KDa. Diameter of inhibition zone of peat soil bacteria is 30 mm, whereas chloramphenicol is 27.5 mm. Antibiotic-like substances produced by peat soil bacteria need to be further characterized and may be able to be developed as antibacterial drug.

Cheryl Wang

Shengli Oilfield Central Hospital, China

Title: Obesity, Inherited homosexuality and LGBT healthcare
Speaker
Biography:

Cheryl Wang has earned her MD from Binzhou Medical College, MSc from Shanghai Jiaotong University and PhD from PLA Medical College. She did Internal Medicine Residency, trained as an Endocrinologist in Donying People’s Hospital, China and did Surgery Residency at Mount Sinai and Rutgers in the United States. She had unique expertise at obesity and diabetes.

Abstract:

One major pathogenesis of obesity is the unbalanced hormones, too much stress hormone steroid and/or not enough “antiobese” happy hormones, endorphin, serotonin, dopamine, and oxytocin, too much estrogen and/or too less testosterone. Any sexual orientation is normal. Sexual orientation is X-linked and Y-linked traits, inherited by next generations. It is like this, female homosexual XAXA, female bisexual XAXa, female straight XaXa, male bisexual XAYA, male homosexual (manly type) XAYa, male homosexual (girlish type) XaYA, male straight XaYa. The presentation and degree of homosexuality varies in many ways, and at different stages of lifespan, as these hormones and our genetic makeup change. So is fat deposition. More
estrogen and/or less testosterone are associated with fat ass. Fat ass may be an easy way to identify stronger homosexuality.
If everybody loves his/her love, it may be better balanced. Yet, the reality is the reality. LGBT healthcare remains far behind. As an unresolved frustration, closeted homosexuality causes a series of health problems, obesity, tobacco/alcohol/substance abuse, and mental/psychiatric disorders. Incautious sexual practice causes sexual transmitted diseases (STDs) like AIDS. Social problems like inequality opportunities among minorities happen often. It brought huge challenge for management. Better acceptance and recognition from learning in a variety way, information merged into clinical visits through smartphone apps and electronic medical record system (ERMS), barrier protection in sexual practice, positive attitude in daily life, team network of physicians, psychiatrists, psychologists, pharmacists, activists, and communities, with loving hearts. Start local, go global, don’t ever shut the door.

Trent Brookshier

Western University of Health Sciences, USA

Title: Renaming pre-diabetes based on patient perception of the disease in order to improve patient compliance and outcomes
Speaker
Biography:

Trent Brookshier is currently pursuing his Medical degree at College of Podiatric Medicine-Western University of Health Sciences (WUCPM). He has pursued his Bachelor in Science degree at UC Irvine.

Abstract:

Diabetes mellitus type-2 affects millions of Americans and is one of the leading causes of death. A few simple steps could make an enormous difference in the management of diabetes. Early detection, effective patient education and patient compliance are some of the ways in which the progression of the disease can be combated. The hypothesis was that using the term prediabetes is not the most effective label when counseling patients on hyperglycemia or insulin insufficiency. A survey testing the perception of prediabetes versus newly coined stage-1 diabetes was conducted to see if patients viewed them differently and how it would influence their decisions. It is found that patients viewed stage-1 diabetes 17% more severely on a ten-point scale and were 20% more likely to see the need for medication when this new name was used. None of those surveyed that currently were diagnosed with prediabetes were on medication but 66% said they would be willing to take medication if they were diagnosed with stage-1 diabetes. Based on the results of the study it is proposed using a new naming system for diabetes mellitus to help improve patient compliance and outcomes.

Yensuari

RSUD Dr. Saiful Anwar, Indonesia

Title: The effect of physical exercise to barrier glomerular filtration system in diabetic rat
Speaker
Biography:

Yensuari is a student of Endocronology-Metabolism and Diabetes Consultant at Division of Endocrinology, Metabolism and Diabetes, Department of Internal
Medicine, Saiful Anwar Hospital, School of Medicine Brawijaya University Malang Indonesia.

Abstract:

Introduction: Albuminuria in hyperglycemia or diabetes occurs due to leakage of the barrier glomerular filtration system. Other causes of albuminuria are insulin resistance, hyperinsulinemia, low-grade inflammation, dysregulation of adipocytokine and metabolic syndrome alone or together and synergistically can cause glomerular damage to the kidneys. Before the occurrence of albuminuria, it was preceded by the occurrence of podocyturia due to damage of glomerular podocytes which is one of the components of the glomerular filtration barrier. Mild and moderate physical exercise in people with diabetes
mellitus will reduce the level of albuminuria, but the mechanism is still unclear.
Aim: To prove the differences in the effect of physical exercise on the barrier of the glomerular filtration system in diabetic rats.
Methods: Four (4) normal sedentary rats, normal physical exercise, sedentary diabetes and diabetes were given physical exercise treatment. Diabetes in rats is induced by giving a high-fat diet for two weeks, then injection of Streptozotocin (STZ) 30 mg/kg (0.1 M citrate buffer, pH 4.5) Intraperitoneal (IP) every week for two weeks. Sedentary treatment, rats remain left in the
cage while physical exercise treatment using a special tool in the form of a treadmill rat (rodent-treadmill), six days a week for 10 weeks (chronic) and moderate intensity, beginning with a speed of 10 meters per minute for 10 minutes per day. The speed and duration of physical exercise is increased gradually every two weeks until it reaches the length of physical exercise one hour per day with a speed of 27 meters per minute. Sometimes metabolic (metabolic cage) urine is collected 24 hours before (pre) and after (post) physical exercise. Levels of albumin, Podocalyxin (PCX) in 24-hour urine were measured by ELISA (Enzyme Linked Immunosorbent Assay) and HOMA IR methods. Hypothesis testing uses paired t test, the data shows mean ±SD with p≤0.05 meaningful.
Results: There was no significant difference in the levels of albumin in the normal group of sedentary rats before and after treatment (p=0.49), while the normal group of physical exercise had a significant increase (p=0.04). The albumin level in the diabetic group increased (p=0.27), while the diabetes exercise group decreased albumin levels (p=0.32). PCX levels in sedentary
normal rats decreased before and after treatment (p=0.42), while the normal group physical exercise increased (p=0.20). In diabetic rats PCX levels increased before and after treatment (p=0.47), while in the diabetes group physical exercise decreased (p=0.71). IR HOMA values decreased in both groups of rats, normal sedentary (p=0.04) and normal physical exercise (p=0.59). The HOMA value of the IR sedentary group increased (p=0.45), while the diabetes group physical exercise before and after treatment decreased (p=0.84).
Conclusion: Chronic physical intensity with moderate intensity can reduce the progressive damage to the glomerular filtration system barrier in diabetics. Selecting the intensity and duration of selective physical exercise is needed to avoid damage to the glomerular filtration system in normal individuals and individuals who have a disease with a tendency to kidney complications such as diabetes.